Content Warning / Educational Disclaimer: This article post contains sensitive topics and reflects Open College UK Limited’s opinions for informational purposes only.

Reports of side effects from weight loss injections such as Ozempic, Wegovy, and Mounjaro are increasing, though the prevalence and severity are still being studied.

These weight loss injections were originally designed and developed specifically to manage type 2 diabetes and for those who are seriously overweight or obese, those people more commonly experiencing diabetes and diabetes related symptoms or insulin related problems.

Some patients have reported appetite suppression while using these medications, and research is ongoing into potential benefits for overeating disorders.

As of June 2025, there are emerging concerns that these medications may impact the effectiveness of oral contraceptives, but further study is needed.

The main action within these injections leads to the suppression of glucagon release and slows down the gastric emptying which promotes satiety ultimately leading to reduced calorific intake and beneficial weight loss within its users.

These processes are now leading to gastrointestinal side effects including bloating, stomach pains or stomach cramps, flatulence and diarrhea.

The most common side effects initially after taking these jabs includes excessive vomiting, feelings of nausea, constipation and constant abdominal cramps, pain and general discomfort along with the above-mentioned periodical daily diarrhea bouts.

These typical symptoms are fairly mild and most people on these jabs will experience these side effects and for some people they can reduce or subside slightly as the user’s bodies adapts and adjusts to the medication.

However, in some cases it’s been reported that they don’t subside and can be very persistent and severe.

Additionally, there have been reports of gastroparesis which is a symptom whereby the stomach empties very slowly which results in continuing nausea and purging otherwise known as vomiting.

And again, in some cases there are increasing reports of rapid significant weight loss and serious nutritional deficiencies and further side effects due to the nutritional deficiencies.

There are some reports of users suffering from pancreatitis which is known as an inflammation of the pancreas which requires urgent medical attention and further medication to treat this condition.

Contraceptive concerns

At the time of writing in June 2025 a newly emerging concern from patients and users of these weight loss drugs are showing an interference with the oral contraceptive efficacy.

It has been suggested that delayed gastric emptying from these medications could affect the absorption of oral contraceptives, though this has not been conclusively proven.

It is also important to add that the side effects previously mentioned such as diarrhea and vomiting can further weaken the effectiveness of the pregnancy pill.

It has now been announced that due to the risk of failing contraception pills it is advised that other forms of contraception are used to reduce the risk of unwanted pregnancies.

Some reports suggest these medications may affect fertility in certain women, but evidence is limited and further research is required.

This process is called the dual effect and enhances the importance of increased contraception for those couples who are not planning on a pregnancy whilst taking these weight loss drug treatments.

The list of side effects gets worse!

Emerging studies are investigating potential links between these medications and mood changes, including symptoms of anxiety or depression.

Some patients are reporting mood disorders or mood changes during and while on these drug treatments.

Individuals with a history of mental health conditions should consult their healthcare provider to discuss potential risks and benefits before use.

Costs and counterfeit drugs!

The costs of these drugs due to the popularity in rapid weight loss has seen private prescriptions for as much as £200 per month. Limited availability has coincided with reports of counterfeit products on the market, which may pose additional health risks.

Recommendations for new users

Bearing in mind both the mild side effects and potential long term side effects associated with these weight loss drugs, anyone considering taking them should discuss this with your healthcare professional such as your GP or medical doctor first, before diving in too fast.

It advised that anyone using these drugs both on the NHS and privately should carefully monitor any side effects and report any symptoms especially psychological and mental related to your health care provider.

Individuals planning pregnancy should discuss the timing of medication use with their healthcare provider.

More serious and long-term side effects

Short term studies have shown there are definite mild low level risk side effects and symptoms which have only been running for currently two years and this period of time is not enough to understand the long-term side effects.

Thyroid C-cell tumours are a growing concern and sight impairment issues!

Animal studies have shown tumour formation in mice, and the relevance to humans is still under investigation.

Many cases of kidney injury have been reported especially from patients who are suffering from severe dehydration as a result of the ongoing diarrhoea and vomiting issues associated with the use of the drug.

Muscle loss!

Some reports suggest that significant weight loss with these medications may include loss of muscle tissue, though evidence is anecdotal and individual experiences vary.

Here are some user’s testimonials and comments regularly circulating.

Some user experiences shared online describe rapid weight loss and adverse symptoms; however, these are anecdotal and individual outcomes may vary. Reports regarding contraceptive failure should be interpreted cautiously and discussed with a healthcare professional.

The final word

Many users of this drug will go to the ends of the earth no matter what to lose weight and will suffer the symptoms irrespective of long-term consequences or advice that is given to them.

For many people and for many reasons no matter what they do they cannot lose weight and this drug has given them the opportunity to lose the weight they’ve always wanted to lose.

If you’re considering taking the drug by anyone’s standard, sound advice would be to really look hard at the options and the safer approach to weight loss such as removing sugar and carbohydrates and possibly looking at a ketogenic diet, carnivore diet or just low sugar and low carbohydrate eating foods combined with exercise.

If you’re looking for a safe alternative to losing weight in a healthy way, you might want to try our training course in weight loss management.

Be wise and stay safe!

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